Holland, Roberto [UNESP]Souza, Valdir de [UNESP]Nery, Mauro Juvenal [UNESP]Otoboni Filho, José Arlindo [UNESP]Bernabé, Pedro Felício Estrada [UNESP]Dezan Júnior, Eloi [UNESP]2014-05-272014-05-271999-11-01Journal of Endodontics, v. 25, n. 11, p. 728-730, 1999.0099-2399http://hdl.handle.net/11449/65871This study was conducted to observe the reaction of apical tissues of dogs' teeth after root canal filling with gutta-percha and mineral trioxide aggregate (MTA) or a glass ionomer (Ketac-Endo) as a sealer. The root canals were instrumented and filled by the lateral condensation technique with the sealers studied. Animals were killed 6 months later, and the specimens were removed and prepared for histological analysis. Results showed no inflammatory reaction of apical tissue and total closure of the apical foramen of all the teeth sealed with MTA. The teeth sealed with Ketac-Endo showed two cases of partial closure and different degrees of chronic inflammatory reaction. In conclusion, MTA exhibited better biological properties than Ketac-Endo. Copyright © 1999 by The American Association of Endodontists.728-730engaluminum derivativecalcium derivativeglass ionomerKetac Endomineral trioxide aggregateoxideroot canal filling materialsilicateanimalcementumcomparative studydogdrug combinationdrug effectperiodontiumtooth pulp diseasetooth rootAluminum CompoundsAnimalsCalcium CompoundsDental CementumDentin, SecondaryDogsDrug CombinationsGlass Ionomer CementsOxidesPeriapical TissueRoot Canal Filling MaterialsSilicatesTooth ApexArtigo10.1016/S0099-2399(99)80118-6WOS:000083523700007Acesso restrito2-s2.0-0033223805533464015936172166857713118618918813777272581972