Nahás, Eliana Aguiar Petri [UNESP]Nahás-Neto, Jorge [UNESP]Pontes, Anaglória [UNESP]Dias, Rogerio [UNESP]Fernandes, César Eduardo2014-05-272014-05-272006-08-31Revista de Psiquiatria Clinica, v. 33, n. 2, p. 68-73, 2006.0101-60831806-938Xhttp://hdl.handle.net/11449/69046Hyperprolactinemia is the most frequent endocrine disorder of the hypothalamus-hypophysis axis observed in women of reproductive age. It is characterized by elevated serum prolactin levels. Prolactin production is regulated by the inhibitory action of a neurotransmitter, dopamine. Clinical manifestations include irregular menstrual cycle, amenorrhea, galactorrhea, infertility and libido decrease, but psychological symptoms, especially anxiety and depression, have also been associated with hyperprolactinemia. Nonetheless, few studies about this condition are available. In the pathogenesis of psychiatric disorders, prolactin may have either a direct action on the central nerve system or an indirect effect via gonadal hormones or function as independent factors as a result of dopamine depletion. Thus, since the prevalence of psychiatric disorders in patients with hyperprolactinemia was detected, it was concluded that further studies are necessary to investigate the basis of a potential relationship between both hyperprolactinemic and psychiatric conditions.68-73porDopamineHyperprolactinemiaPsychiatric disordersdopamineprolactinamenorrheaanxietycentral nervous systemclinical featuredepressiondisease associationendocrine diseasegalactorrheahumanhyperprolactinemiahypothalamus hypophysis systeminfertilitylibido disordermenstrual cyclemental diseaseprolactin blood levelreviewArtigo10.1590/S0101-60832006000200006S0101-60832006000200006Acesso aberto2-s2.0-337478552552-s2.0-33747855255.pdf415517057478841705141786546676849476843874583499