Mostachio, Giuliano QueirozApparício, Maricy [UNESP]Motheo, Tathiana Ferguson [UNESP]Alves, Aracélle ElisaneVicente, Wilter Ricardo Russiano [UNESP]2018-12-112018-12-112015-01-01Ciencia Rural, v. 45, n. 9, p. 1654-1659, 2015.1678-45960103-8478http://hdl.handle.net/11449/177468The pathogenesis of benign prostatic hyperplasia (BPH) is not completely known, however, dihydrotestosterone is a hormone involved in enlargement of the prostate. Recently, the effect of botulinum toxin A (BT-A) was investigated and has shown to induce atrophy of the gland. Based on that, the aims of this study were to compare the effects of administration of BT-A with orchiectomy in the treatment of BPH, in addition to assessing the effects of BT-A on libido and semen quality. Therefore, 16 sexually intact male dogs were submitted to orchiectomy or administration of 500U BT-A, and evaluated for 16 weeks. Orchiectomy presented excellent results, reducing the prostate volume up to 80%. Administration of BT-A did not interfered on libido, erection or semen characteristics. On the other hand, reduced significantly the prostate volume. The results suggest that intraprostatic injection of BT-A is an effective alternative treatment without adverse effects for valuable breeding dogs with BPH. However, this therapy showed lower reduction of prostate volume when compared to orchiectomy.1654-1659porBPHDogNeurotoxinOrchiectomyProstateSemenArtigo10.1590/0103-8478cr20141253S0103-84782015000901654Acesso aberto2-s2.0-84940105599S0103-84782015000901654.pdf