Paiva, Sergio Alberto Rupp de [UNESP]Godoy, Irma de [UNESP]Vannucchi, HélioFávaro, Rosa M. D.Geraldo, Rosana R. C.Campana, Alvaro O.2014-05-272014-05-271996-12-01American Journal of Clinical Nutrition, v. 64, n. 6, p. 928-934, 1996.0002-9165http://hdl.handle.net/11449/64880The relation between vitamin A status and the degree of lung airway obstruction was examined in a cross-sectional study of 36 male subjects aged 43-74 y who were assigned to five groups as follows: healthy nonsmokers (n = 7), healthy smokers (n = 7), mild chronic obstructive pulmonary disease (COPD-mild) patients (n = 9), COPD-moderate-severe patients (n = 7), and COPD-moderate-severe patients with exacerbation (+ex; n = 6). Smoking habits, pulmonary function tests, and energy-protein status were assessed; serum concentrations of retinyl esters, retinol, retinol binding protein, and transthyretin and relative dose responses were measured. In addition, 12 male smokers aged 45-61 y with mild COPD were randomly assigned to two groups for a longitudinal study: six subjects consumed vitamin A (1000 RE/d; COPD- vitamin A) and six subjects received placebo for 30 d. Lowered serum retinol concentrations were found in the COPD-moderate-severe and COPD-moderate- severe+ex groups. Measurements of vitamin A status in healthy smokers and in COPD-mild patients were not different from those in healthy nonsmokers. The improvement of pulmonary function test results after vitamin A supplementation [mean increase for 1-s forced expiratory volume (FEV1) = 22.9% in the COPD-vitamin A group] may support the assumption of a local (respiratory) vitamin A deficiency in patients with this disease.928-934engchronic obstructive pulmonary diseasepulmonary function testsretinol circulating complexVitamin A status assessmentacute phase proteinalbuminalpha carotenebeta carotenec reactive proteinceruloplasminplaceboprealbuminretinol binding proteinretinol esterretinol palmitateairway obstructionchronic obstructive lung diseasecigarette smokingclinical protocolclinical trialcontrolled clinical trialcontrolled studydiet supplementationdisease severityforced expiratory volumelung function testnutritional statusoral drug administrationrandomized controlled trialretinol deficiencyvitamin blood levelAnalysis of VarianceCarotenoidsCross-Sectional StudiesDietIntestinal AbsorptionLiverLongitudinal StudiesLungLung Diseases, ObstructiveMiddle AgedNutritional StatusRespiratory Function TestsSmokingVitamin AVitamin A DeficiencyArtigoWOS:A1996VU81400016Acesso restrito2-s2.0-00298506355079454858778041