Lima, Alex Ranieri JerônimoRibeiro, GabrielaViala, Vincent Louisde Lima, Loyze Paola OliveiraMartins, Antonio JorgeBarros, Claudia Renata dos SantosMarqueze, Elaine CristinaBernardino, Jardelina de Souza TodaoMoretti, Debora BotequioRodrigues, Evandra StrazzaSantos, Elaine VieiraBrassaloti, Ricardo AugustoCassano, Raquel de Lello Rocha CamposMariani, Pilar Drummond Sampaio CorrêaClemente, Luan GasparAssato, Patricia Akemi [UNESP]Costa, Felipe Allan da Silva da [UNESP]Poleti, Mirele DaianaLesbon, Jessika Cristina ChagasMattos, Elisangela ChicaroniBanho, Cecilia ArticoSacchetto, LíviaMoraes, Marília MazziPalmieri, MelissaMartininghi, MaiaraCaldeira, Luiz Artur VieiraSilva, Fabiana Erica Vilanova daGrotto, Rejane Maria Tommasini [UNESP]Souza-Neto, Jayme A. [UNESP]Giovanetti, MartaJunior Alcantara, Luiz CarlosNogueira, Maurício LacerdaFukumasu, HeidgeCoutinho, Luiz LehmannKashima, SimoneNeto, Raul MachadoCovas, Dimas TadeuSlavov, Svetoslav NanevSampaio, Sandra CoccuzzoElias, Maria Carolina2022-04-282022-04-282022-01-01Journal of Medical Virology.1096-90710146-6615http://hdl.handle.net/11449/223588Delta VOC is highly diverse with more than 120 sublineages already described as of November 30, 2021. In this study, through active monitoring of circulating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants in the state of São Paulo, southeast Brazil, we identified two emerging sublineages from the ancestral AY.43 strain which were classified as AY.43.1 and AY.43.2. These sublineages were defined by the following characteristic nonsynonymous mutations ORF1ab:A4133V and ORF3a:T14I for the AY.43.1 and ORF1ab:G1155C for the AY.43.2 and our analysis reveals that they might have a likely-Brazilian origin. Much is still unknown regarding their dissemination in the state of São Paulo and Brazil as well as their potential impact on the ongoing vaccination process. However, the results obtained in this study reinforce the importance of genomic surveillance activity for timely identification of emerging SARS-CoV-2 variants which can impact the ongoing SARS-CoV-2 vaccination and public health policies.engAY.43Delta VOCemerging sublineagesgenomic surveillanceSARS-CoV-2Artigo10.1002/jmv.276742-s2.0-85125997787