Antonio, Tatiana [UNESP]Bellão, CarolinaCorrêa, Tatiana [UNESP]Cavallieri, André Pastrelo [UNESP]Badino, Alberto ColliAraujo, Maria Lucia Gonsales da Costa [UNESP]2014-05-202014-05-202012-12-01Brazilian Archives of Biology and Technology. Brazilian Archives of Biology and Technology, v. 55, n. 6, p. 819-825, 2012.1516-8913http://hdl.handle.net/11449/25248The aim of this work was to compare the composition of a complex and soluble culture medium to eight other media described in the literature through the batch cultivation in a conventional bench-scale bioreactor for the production of cephamycin C by a wild strain of Streptomyces clavuligerus. The proposed medium resulted in an antibiotic production 1.5 to 7.5 times higher than the other culture media.819-825engβ-lactam antibioticStreptomyces clavuligeruslysine metabolismcomplex mediumArtigo10.1590/S1516-89132012000600003S1516-89132012000600003WOS:000313343000003Acesso abertoS1516-89132012000600003.pdf2478051365107560