Lopes, Laís C. [UNESP]Bueno, Paulo R. [UNESP]2022-05-012022-05-012021-09-08Analytica Chimica Acta, v. 1177.1873-43240003-2670http://hdl.handle.net/11449/233203We demonstrated that the variations measured in the quantum capacitance of single-layer graphene, envisioned here as a conceptual molecular model, depend on the chemical reactivity of the molecule and can be used as an analytical and sensing tool for environmental conditions. The variations are quantized as a function of the environmental changes and can be correlated with chemical reactivity indexes such as chemical hardness and softness. This not only constitutes a proof-of-principle that the chemical reactivity of graphene, as a single molecule, can be determined in situ by measuring the quantum capacitance, but also that these measurements can be used as an analytical tool.engChemical hardnessConceptual density functional theoryGrapheneImpedance spectroscopyQuantum capacitanceSingle-molecule capacitanceArtigo10.1016/j.aca.2021.3387352-s2.0-85108812921