Carlos, Iracilda Z. [UNESP]Carli, Camila B. A. [UNESP]Maia, Danielle C. G. [UNESP]Benzatti, Fernanda P. [UNESP]Lopes, Flavia C. M. [UNESP]Roese, Fernanda M.Watanabe, MárcioMicheletti, Ana C.Santos, Lourdes Campaner dos [UNESP]Vilegas, Wagner [UNESP]Honda, Neli K.2014-05-272014-05-272009-10-01Brazilian Journal of Pharmacognosy, v. 19, n. 4, p. 847-852, 2009.0102-695Xhttp://hdl.handle.net/11449/71177The effects of isolated compounds from Brazilian lichens and their derivatives on H 2O 2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H 2O 2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H 2O 2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.847-852engHydrogen peroxideLichensMacrophagesNitric oxidePhenolic compounds8' o n propyl norstitic acid9' o ethyl norstitic acid9' o ethyl protocetraric acid9' o iso propyl protocetraric acid9' o methyl protocetraric acid9' o n butyl protocetraric acid9' o n hexyl protocetraric acid9' o n pentyl protocetraric acid9' o n propyl protocetraric acid9' o sec butyl protocetraric acid9' o terc butyl protocetraric acidcomprotocetraric acidhydrogen peroxideimmunostimulating agentlichexanthonemethyl protocetratenitric oxidenitroblue tetrazoliumnorstitic acidphenol derivativephysodic acidprotocetraric acidunclassified druganimal cellcell stimulationcell viabilitycytotoxicitydrug determinationdrug structuredrug synthesisimmune responseimmunomodulationlichenmacrophagemousenonhumanperitoneumstructure activity relationsupernatantSwiss Webster mouseArtigo10.1590/S0102-695X2009000600009S0102-695X2009000600009WOS:000275593200009Acesso aberto2-s2.0-779495146312-s2.0-77949514631.pdf35382536406029770000-0003-3032-2556