Pontinha, A. D. R.Jorge, S. M. A. [UNESP]Diculescu, V. C.Vivan, M.Oliveira-Brett, A. M.2014-05-202014-05-202012-04-01Electroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 24, n. 4, p. 917-923, 2012.1040-0397http://hdl.handle.net/11449/19103Methotrexate (MTX) is an antimetabolite of folic acid indicated in the treatment of a variety of cancers. The electrochemical behaviour of MTX on a glassy carbon electrode was investigated. The MTX oxidation is a complex, pH-dependent, diffusion-controlled irreversible process and proceeds with the transfer of two electrons and two protons and the formation of one electroactive product, 7-hydroxymethotrexate that undergoes a reversible redox reaction. The MTX reduction is a pH-dependent, quasi-reversible process and involves the transfer of two electrons and two protons leading to the formation of an electroactive product.917-923engGlassy carbonMethotrexateOxidationReductionArtigo10.1002/elan.201100558WOS:000302160000026Acesso restrito5216150705972509