Steffens, Joao PauloSantos, Fábio AndréSartori, RafaelPilatti, Gibson Luiz2014-05-272014-05-272010-08-01Journal of Periodontology, v. 81, n. 8, p. 1153-1160, 2010.0022-3492http://hdl.handle.net/11449/71801Background: Several anti-inflammatory drugs have been used to reduce pain and discomfort after periodontal surgeries. This study evaluates the efficacy of using etoricoxib and dexamethasone for pain prevention after open-flap debridement surgery. Methods: For this prospective, double-masked, crossover, placebo-controlled, randomized clinical trial, open-flap debridement surgeries were performed on 15 patients (eight males and seven females, age range 20 to 56 years: mean age ± SD: 40 ± 9.7 years) who presented with chronic periodontitis after nonsurgical periodontal therapy at three quadrants. Each patient underwent three surgical procedures at intervals of 30 days and received one of the following premedication protocols 1-hour before surgery: group 1 = placebo, group 2 = 8 mg dexamethasone, and group 3 = 120 mg etoricoxib. Rescue medication (750 mg acetaminophen) was given to each patient who was instructed to take it when necessary. Pain intensity and discomfort were evaluated by a 101-point numeric rate scale and a four-point verbal rate scale, respectively, hourly for the first 8 hours after surgery and three times a day on the following 3 days. Results: The results demonstrate that groups 2 and 3 present reduced postoperative pain-intensity levels compared to group 1. There were statistically significant differences at the 4, 5, 6, 7, and 8 hour-periods after surgery (Friedman test; P<0.05). Furthermore, rescue-medication intake was significantly lower for groups 2 and 3 than for group 1 (analysis of variance; P<0.02). Conclusion: The adoption of a preemptive medication protocol using etoricoxib or dexamethasone may be considered effective for pain and discomfort prevention after open-flap debridement surgeries.1153-1160engAnalgesiaDexamethasoneEtoricoxibPainPain measurementPreanesthetic medicationanalgesic agentantiinflammatory agentcyclooxygenase 2 inhibitordexamethasoneetoricoxibglucocorticoidparacetamolplacebopyridine derivativesulfoneadolescentadultchronic periodontitisclinical trialcomparative studycontrolled clinical trialcontrolled studycrossover proceduredental anxietydouble blind procedurefemalefollow uphumanmalemiddle agedpain assessmentplastic surgerypostoperative painpremedicationprospective studypsychological aspectrandomized controlled trialsex differencetreatment outcomeAcetaminophenAdolescentAdultAnalgesics, Non-NarcoticAnti-Inflammatory AgentsChronic PeriodontitisCross-Over StudiesCyclooxygenase 2 InhibitorsDental AnxietyDouble-Blind MethodFemaleFollow-Up StudiesGlucocorticoidsHumansMaleMiddle AgedPain MeasurementPain, PostoperativePlacebosPremedicationProspective StudiesPyridinesSex FactorsSulfonesSurgical FlapsTreatment OutcomeYoung AdultArtigo10.1902/jop.2010.100059Acesso restrito2-s2.0-77955392807