Meira, Cezinande de [UNESP]Pessoa, Valsair MatosFerreira, João Carlos Pinheiro [UNESP]Araujo, Gustavo Henrique M.Gioso, Marilu M.Bicudo, Sony Dimas [UNESP]Oba, Eunice [UNESP]Orlandi, Cassia2014-02-262014-05-202014-02-262014-05-202006-12-01Journal of Veterinary Science. Seoul: Korean Society Veterinary Science, v. 7, n. 4, p. 387-390, 2006.1229-845Xhttp://hdl.handle.net/11449/14492The present study was conducted in order to verify the efficacy of lower doses and alternative routes of a prostaglandin F2 alpha analogue, luprostiol (PGF), for the induction of luteolysis and the precipitation of estrus in nonlactating Nelore cows (Bos taurus indicus). A conventional dose (15 mg) of PGF was compared to doses lower than the conventional dose, which ranges from 10 to 50%, that were administered intramuscularly (IM), intravulvosubmucosally (IVSM), or in the Bai-hui acupuncture site located within the lumbosacral area. The cows were administered PGF 8 day after estrus in the presence of a corpus luteum, and randomly assigned to the following groups: G1 (positive control), 15 mg, IM (n = 23); G2, 7.5 mg, IM (n = 23); G3, 3.75 mg, I M (n = 24); G4, 7.5 mg, IVSM (n = 25); G5, 3.75 mg, Bai-hui acupoint (n = 24); and G6, 1.5 mg, Bai-hui acupoint (n = 25). The results indicated that 50% of a conventional dose of PGF (7.5 mg) resulted in a complete luteal regression (plasma progesterone < 1 ng/ml) at Hour 48, and hastened estrus, regardless of whether or not PGF was administered IM or IVSM. Comparatively, 10 or 25% of the conventional dose, even when administered to the Bai-hui acupoint, resulted in an initial reduction in the concentration of progesterone at Hour 24, followed by an increase observed at Hour 48. In conclusion, 25% of a conventional PGF dose administered via the Bai-hui acupoint proved inadequate to induce a complete luteal regression, whereas 50% of a conventional dose administered IM or IVSM was found to be the minimal dose required to induce effectively a complete luteal regression, and to precipitate the onset of estrus in nonlactating Nelore cows.387-390engbai-hui acupointcowsluprostiolluteolysisprogesteroneprostaglandinArtigo10.4142/jvs.2006.7.4.387WOS:000242818900014Acesso abertoWOS000242818900014.pdf00429054157111993569421209341579813460627091386092243805865576640000-0002-2245-800X