Caritá, Amanda CostaFonseca-Santos, Bruno [UNESP]Shultz, Jemima Daniela [UNESP]Michniak-Kohn, BozenaChorilli, Marlus [UNESP]Leonardi, Gislaine Ricci2020-12-122020-12-122020-02-01Nanomedicine: Nanotechnology, Biology, and Medicine, v. 24.1549-96421549-9634http://hdl.handle.net/11449/199645Vitamin C (Vit C) is a potent antioxidant with several applications in the cosmetic and pharmaceutical fields. However, the biggest challenge in the utilization of Vit C is to maintain its stability and improve its delivery to the active site. Several strategies have been developed such as: controlling the oxygen levels during formulation and storage, low pH, reduction of water content in the formulation and the addition of preservative agents. Additionally, the utilization of derivatives of Vit C and the development of micro and nanoencapsulated delivery systems have been highlighted. In this article, the multiple applications and mechanisms of action of vitamin C will be reviewed and discussed, as well as the new possibilities of delivery and improvement of stability.engAscorbic acidDrug deliveryLiposomesMicroemulsionsNanoparticlesTargetingResenha10.1016/j.nano.2019.1021172-s2.0-85074885471