Panontin, Juliane FarinelliBarbosa, Robson dos SantosIsaac, Vera [UNESP]Seibert, Carla SimoneScapin, Elisandra2022-04-282022-04-282022-01-01Natural Product Research.1478-64271478-6419http://hdl.handle.net/11449/223725The goal of this work was to chemically characterise Hancornia speciosa extracts to develop an antioxidant serum formulation. Stem and bark extracts were prepared using 70% hydroethanol solution by Sohxlet and ultrasound assisted extraction. The content of total phenols, flavonoids, and antioxidant activity were evaluated, and chemical characterization was performed by HPLC -detector UV-VIS (SPD − 10 A). The formulation was developed with stem extract (0.250 mg/g) in hydroxyethylcellulose fluid gel. Stem extracts had higher total phenols and flavonoids, and higher antioxidant activity than bark extracts. The formulation presented low viscosity, a yellowish colour, 81.28% ± 0.14 of antioxidant activity. In the stability test, the physicochemical characteristics showed small variations, remaining more stable at a temperature of 5 °C, with an antioxidant activity of 64.81% ± 0.75. Therefore, the stem of H. speciosa has the potential to be used in antioxidant formulations.enganti-ageingDPPHMangabeiraphenolic compoundsphytocosmeticsArtigo10.1080/14786419.2022.20539682-s2.0-85127244209