Schellini, Silvana Artioli [UNESP]Hirai, Flavio Eduardo [UNESP]Hoyama, Erika [UNESP]Mattos, Maila Karina [UNESP]Chaves, Fernando Rodrigo [UNESP]Pellizzon, Claudia Helena [UNESP]Padovani, Carlos Roberto [UNESP]2014-05-272014-05-272009-11-09Orbit, v. 28, n. 2-3, p. 104-109, 2009.0167-68301744-5108http://hdl.handle.net/11449/71235Purpose: To present a technique for filling facial folds by using autologous orbicularis oculi muscle, based on an experimental model. Methods: two studies are presented: (1) an experimental study using 15 albino guinea-pigs from which a strip of the sural triceps muscle was removed and implanted in the subcutaneous tissue of the dorsal area. The animals were sacrificed 7, 30 and 60 days after the implantation, and the material was histologically evaluated. And (2%) an interventional prospective clinical trial carried out on 20 patients referred to blepharoplasty surgery. They received autologous preseptal orbicularis muscle for filling facial folds. The results where evaluated by patients satisfaction and clinical exam. Results: the sural tricep muscle, when implanted in the subcutaneous tissue, resulted in fibrosis. The patients whom received autologous orbicularis muscle implanted for filling facial folds showed that the procedure can be successfully carried out. Conclusions: autologous preseptal orbicularis muscle is a good material for filling facial folds. Cicatricial tissue will be formed on its implantation site, filling the tissue gap that forms the folds on the skin.104-109engAutologous implantBlepharoplastyFacial foldsFillingOrbicularis oculi muscleadultanimal experimentanimal tissueclinical trialcontrolled studyexperimental modelexperimental studyextraocular muscleeyelid reconstructionfemalefibrosisguinea pighistopathologyhumanhuman experimentmalemuscle graftnonhumannormal humanorbicular musclepatient satisfactionprospective studyskinskinfoldsubcutaneous tissuesurgical techniquetissue reactiontriceps brachii muscleAdultAnimalsDisease Models, AnimalEstheticsEyelidsFacial MusclesFemaleFollow-Up StudiesGuinea PigsHumansImmunohistochemistryIntervention StudiesMaleMiddle AgedOculomotor MusclesProspective StudiesRejuvenationRhytidoplastyTime FactorsTransplantation, AutologousTreatment OutcomeArtigo10.1080/01676830802656455Acesso restrito2-s2.0-70350666510942024910083549200193937798010690000-0002-4494-4180