Ribeiro, Paulo R. S.Pezza, Leonardo [UNESP]Pezza, Helena Redigolo [UNESP]Tognolli, Joao O. [UNESP]2014-05-202014-05-202011-08-01Latin American Journal of Pharmacy. La Plata: Colegio Farmaceuticos Provincia de Buenos Aires, v. 30, n. 6, p. 1158-1166, 2011.0326-2383http://hdl.handle.net/11449/26117A new spectrophotometric method was developed for the determination of captopril (n donor) through charge transfer complex formation with p-chloranil (pi acceptor). The different experimental parameters that affect the absorbance intensity were carefully studied. Thus, these parameters were optimized using chemometric methods of fractional factorial and central composite design. At the optimum reaction conditions, the rectilinear calibration graphs were obtained in the concentration range 1.86 x 10(-4) to 738 x 10(-4) mol/L captopril with an excellent correlation coefficient (r = 0.9996). The proposed procedure could be applied successfully for the determination of the investigated drug in their pharmaceutical dosage forms with a good precision and accuracy compared to official and reported method as revealed by F- and t-tests at 95 % confidence level. No interference was observed from common excipients in formulations.1158-1166engCaptoprilCharge transfer complexChemometric methodsPharmaceuticals formulationsArtigoWOS:000296990200017Acesso restrito597890859185352431921250983611210000-0003-0197-7369