Aparecido Da Silva, Marcelo [UNESP]Murino Rafacho, Bruna Paola [UNESP]Hiruma-Lima, Clelia Akiko [UNESP]Machado Da Rocha, Lúcia Regina [UNESP]Campaner Dos Santos, Lourdes [UNESP]Sannomiya, Miriam [UNESP]Monteiro Souza-Brito, Alba ReginaVilegas, Wagner [UNESP]2014-05-272014-05-272005-08-01Chemical and Pharmaceutical Bulletin, v. 53, n. 8, p. 881-885, 2005.0009-2363http://hdl.handle.net/11449/68357Strychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.881-885engAlkaloidAntiulcer activityStrychnos pseudoquinaToxic activitypiroxicamplant extractstrychnos pseudoquina extractunclassified druganimal experimentanimal modelanimal tissueconcentration responsecontrolled studydrug dose regimendrug effectdrug isolationdrug screeningin vivo studymalemedicinal plantmortalitymousenonhumanphytochemistryplant leafstomach mucosastomach protectionstomach ulcerstrychnos pseudoquinaAnimalsAnti-Inflammatory Agents, Non-SteroidalDrug Evaluation, PreclinicalGastric MucosaMicePlant ExtractsPlant LeavesStomach UlcerStrychnosArtigo10.1248/cpb.53.881WOS:000231320700002Acesso aberto2-s2.0-2494456775938145049013868440000-0002-8645-37770000-0003-3032-2556