Pereira da Silva, Victor HugoGomes de Moura, Carolina FootPidone Ribeiro, Flavia AndressaCesar, AugustoSeabra Pereira, Camilo DiasDias Silva, Marcelo Jose [UNESP]Vilegas, Wagner [UNESP]Ribeiro, Daniel Araki2015-03-182015-03-182014-11-01Environmental Science And Pollution Research. Heidelberg: Springer Heidelberg, v. 21, n. 22, p. 13069-13080, 2014.0944-1344http://hdl.handle.net/11449/116360The aim of this study was to evaluate cytotoxicity and genotoxicity in multiple organs of rats induced by municipal effluent released by submarine outfall in city of Santos. A total of 20 male Wistar rats were exposed to effluents by drinking water ad libitum at concentrations of 0, 10, 50, and 100% for 30 days. Microscopic analysis revealed severe lesions such as necrosis and hemorrhagic areas in liver and kidney from animals exposed to effluent at 50 and 100% concentration. DNA damage in peripheral blood, liver, and kidney cells were detected by comet assay at higher concentrations of effluent. Moreover, a decrease DNA repair capacity was detected in liver cells. Significant statistical differences (p<0.05) for micronucleated cells from liver were noticed at 50% concentration of effluent. Taken together, our results demonstrate that municipal effluent is able to induce cytotoxicity and genotoxicity in multiple organs of Wistar rats.13069-13080engMunicipal effluentApoptosisMutagenicityDNA damageRatArtigo10.1007/s11356-014-3261-5WOS:000344546900043Acesso restrito79278772243268370000-0003-3032-2556