Nicolás Hopp, Renato [UNESP]de Souza Lima, Nathália CarolineFilho, José LaurentinoFilho, Marcondes SenaLima, Carmen Silvia PassosJorge, Jacks2014-05-272014-05-272013-05-01Early Human Development, v. 89, n. 5, p. 327-329, 2013.0378-37821872-6232http://hdl.handle.net/11449/75206Background: Sex steroid exposure during early human development may influence disease susceptibility. Digit ratio (2D:4D) is a putative marker for prenatal hormone exposure and sensitivity, as well as the action of genes closely related to carcinogenesis. Digit ratio could act as a possible marker for cancer predisposition. Aims: The aim of this study is to investigate the possible correlations between right hand, left hand and right minus left (R. - L) 2D:4D and gastric cancer (GCA) in men and women and assess the correlations with tumor staging and histological diagnosis. Methods: Digital images of the right and left hand palms of patients diagnosed with GCA (n = 57, 42 males, 15 females) and age and sex-matched controls (n = 59, 41 males, 18 females) were obtained. Means for 2D:4D were compared. Data were analyzed by repeated-measures one-way ANOVA and Student's t-test for finger measurements and group comparisons and Pearson's and Spearman's tests for correlations with tumor staging (α = 0.05). Results: GCA group presented significantly higher left 2D:4D, but significantly lower R. - L in comparison to healthy controls, particularly so for males. Digit ratio did not correlate to clinical staging or TNM staging. However, low R. - L was significantly related to adenocarcinomas. Conclusions: Early developmental conditions, including prenatal testosterone seem to play a role on the malignant transformation of gastric lesions. The 2D:4D pattern found for gastric cancer parallels that earlier described for breast cancer. The findings suggest that 2D:4D could add to the list of etiological factors and be a putative marker for the screening of patients' susceptibility to develop gastric cancer. © 2012 Elsevier Ltd.327-329eng2D:4DDigit ratioGastric cancerestrogentestosteroneadultagedanalysis of variancecancer stagingcancer susceptibilitycontrolled studydisease associationfemalegenderhand palmhistologyhumanmajor clinical studymalemalignant transformationmeasurement repeatabilityretrospective studystomach adenocarcinomastomach cancerstomach lesionStudent t testtumor volumeArtigo10.1016/j.earlhumdev.2012.11.002WOS:000318387600012Acesso restrito2-s2.0-84876102863