Laskoski, Luciane MariaLocatelli-Dittrich, RosangelaValadão, Carlos Augusto Araújo [UNESP]Deconto, IvanGonçalves, Kamila AlcalaMontiani-Ferreira, FabianoBrum, Juliana SperottoBrito, Harald Fernando Vicente deSousa, Renato Silva de2015-12-072015-12-072015Research In Veterinary Science, v. 101, p. 15-21, 2015.1532-2661http://hdl.handle.net/11449/131415The present study was aimed at identifying laminar lesions and leukocyte infiltration in hoof laminar tissue of horses with colic syndrome and its correlation with the total leukocyte count before death. Six healthy horses were used as control group (CG), and eighteen horses with lethal gastrointestinal disease were divided into two groups: leukopenic group (LG) with seven leukopenic horses, and non-leukopenic group (NLG) with 11 horses with total leukocyte count within reference range for the species. Leukocyte infiltration was examined by immunohistochemistry. Laminar lesions were observed in both LG and NLG, with no differences in severity between them. LG showed increase of the leukocyte infiltration in the hoof laminar tissue, when compared to CG and NLG. Horses with severe colic syndrome (LG and NLG) developed intense laminar lesions without clinical signs of laminitis, with increased leukocyte infiltration. However, the LG demonstrated an even higher increase of leukocyte infiltration compared to both CG and NLG.15-21engColic syndromeEquineHistopathologyImmunohistochemistryLaminitisArtigo10.1016/j.rvsc.2015.05.014Acesso restrito26267083