Efeito do uso do cogumelo Agaricus brasiliensis no estado nutricional, na frequência e intensidade dos efeitos adversos da terapia medicamentosa e na resposta bioquímica hepática em indivíduos com hepatite crônica pelo vírus C: estudo prospectivo, randomizado, duplo cego, placebo controlado
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Data
2009-07-23
Autores
Cornacini, Milena Costa Menezes [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Diversos estudos, indicam que o cogumelo Agaricus brasiliensis é benéfico em várias condições clínicas, como na hepatite C. Várias espécies de cogumelos comestíveis têm sido exploradas quanto ao seu potencial medicinal e muitos pacientes passam a buscar a solução para suas patologias nas terapias complementares. Avaliar os efeitos da suplementação do Agaricus brasiliensis sobre o estado nutricional, a frequência e a intensidade dos efeitos adversos da terapia antiviral e a resposta bioquímica hepática em indivíduos com hepatite C em tratamento com Interferon peguilado e Ribavirina. Foi realizado um ensaio clínico prospectivo controlado casualizado duplo cego no Serviço de Hepatites Virais do Hospital das Clínicas da Faculdade de Medicina de Botucatu-UNESP. Os indivíduos do estudo foram submetidos a um protocolo de suplementação com cogumelo ou placebo por 24 semanas, e foram distribuídos aleatoriamente nos seguintes grupos: Grupo tratado com placebo (5g/dia n=14) e Grupo tratado com cogumelo (5g/dian= 9).Todas as análises foram obtidas antes e após os tratamentos (placebo ou cogumelo). O estado nutricional (dados antropométricos, de composição corporal, da bioquímica nutricional e do consumo alimentar), foi semelhante entre os grupos. Houve melhora da lesão hepática em ambos os grupos, com redução de transaminases (TGO/AST e TGP/ALT, p<0,05), mostrando a eficácia do tratamento antiviral.O uso do cogumelo mostrou-se benéfico na redução da frequência e intensidade dos efeitos adversos da terapia medicamentosa (mialgia, disgeusia, cefaléia, redução do desejo sexual, queda de cabelo, hipoanorexia, indisposição, boca seca e irritabilidade, p<0,05). Em pacientes com hepatite C, a suplementação de cogumelo Agaricus brasiliensis (5g) por 24 semanas mostrou-se eficiente em reduzir a frequência...
Several studies indicate that the Agaricus brasiliensis is beneficial in various clinical conditions, such as hepatitis C. Several species of edible fungi have been explored as to its potential medical and many patients now have to seek a solution to their condition in complementary therapies. Objective: To evaluate the effects of supplementation of Agaricus brasiliensis on the nutritional status, the frequency of adverse effects of antiviral therapy and liver damage in patients with hepatitis C treated with pegylated interferon and ribavirin. We performed a prospective trial randomized controlled double-blind in the service of Viral Hepatitis Hospital of the Medical School of Botucatu, UNESP. Those in the study were subjected to a memorandum of supplementation with mushroom or placebo for 24 weeks, and were randomly distributed in the following groups: placebo-treated group (5g/dia n = 14) and mushroom-treated group (n 5g/dia- = 9). All tests were obtained before and after the treatments (placebo or mushroom). The nutritional status (anthropometric data, body composition, nutrition and biochemistry of food intake), was similar between the groups. There was improvement of liver damage in both groups, reducing transaminase (AST / ALT and AST / ALT, p <0.05), demonstrating the effectiveness of treatment antiviral use of the mushroom was shown to be beneficial in reducing the frequency and intensity of the adverse effects of drug therapy (myalgia, dysgeusia, headache, reduction in sexual desire, hair loss, hipoanorexia, malaise, dry mouth and irritability, p <0.05). In patients with hepatitis C, the supplementation of Agaricus brasiliensis (5) for 24 weeks proved to be effective in reducing the frequency and intensity of the adverse effects of drug therapy with pegylated interferon and ribavirin, and on the other hand, was inefficient for nutritional status and liver damage.
Several studies indicate that the Agaricus brasiliensis is beneficial in various clinical conditions, such as hepatitis C. Several species of edible fungi have been explored as to its potential medical and many patients now have to seek a solution to their condition in complementary therapies. Objective: To evaluate the effects of supplementation of Agaricus brasiliensis on the nutritional status, the frequency of adverse effects of antiviral therapy and liver damage in patients with hepatitis C treated with pegylated interferon and ribavirin. We performed a prospective trial randomized controlled double-blind in the service of Viral Hepatitis Hospital of the Medical School of Botucatu, UNESP. Those in the study were subjected to a memorandum of supplementation with mushroom or placebo for 24 weeks, and were randomly distributed in the following groups: placebo-treated group (5g/dia n = 14) and mushroom-treated group (n 5g/dia- = 9). All tests were obtained before and after the treatments (placebo or mushroom). The nutritional status (anthropometric data, body composition, nutrition and biochemistry of food intake), was similar between the groups. There was improvement of liver damage in both groups, reducing transaminase (AST / ALT and AST / ALT, p <0.05), demonstrating the effectiveness of treatment antiviral use of the mushroom was shown to be beneficial in reducing the frequency and intensity of the adverse effects of drug therapy (myalgia, dysgeusia, headache, reduction in sexual desire, hair loss, hipoanorexia, malaise, dry mouth and irritability, p <0.05). In patients with hepatitis C, the supplementation of Agaricus brasiliensis (5) for 24 weeks proved to be effective in reducing the frequency and intensity of the adverse effects of drug therapy with pegylated interferon and ribavirin, and on the other hand, was inefficient for nutritional status and liver damage.
Descrição
Palavras-chave
Hepatite C, Clinical nutrition, Adverse effects, Hepatitis C, Antiviral treatment
Como citar
CORNACINI, Milena Costa Menezes. Efeito do uso do cogumelo Agaricus brasiliensis no estado nutricional, na frequência e intensidade dos efeitos adversos da terapia medicamentosa e na resposta bioquímica hepática em indivíduos com hepatite crônica pelo vírus C: estudo prospectivo, randomizado, duplo cego, placebo controlado. 2009. 138 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2009.