Prevalência de microrganismos potencialmente superinfectantes na cavidade bucal de pacientes com Lúpus Eritematoso Sistêmico
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Data
2009-11-23
Autores
Navas, Edna Aparecida Ferraz de Araujo [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Considerando-se que pacientes com Lúpus Eritematoso Sistêmico são submetidos a tratamento com corticosteróides e imunossupressores, podemos concluir que esta condição pode interferir na presença de microrganismos potencialmente oportunistas na cavidade bucal. Deste modo, o objetivo deste estudo foi avaliar a presença de leveduras do gênero Candida, estafilococos, enterobactérias e Pseudomonas spp. na cavidade bucal de pacientes com LES comparando os resultados com indivíduos controle. Desta forma, foram selecionados 40 pacientes com idades entre 19 e 53 anos com LES e que estavam em tratamento por no mínimo 60 dias. Para o grupo controle foram selecionados 40 indivíduos sistemicamente saudáveis com perfil semelhante (quanto à idade, gênero e condições bucais) aos pacientes do grupo em estudo. Não foram incluídos pacientes diabéticos, portadores de próteses bucais totais e outras doenças sistêmicas e que estavam sob terapia com medicamentos que pudessem interferir com as condições bucais. Foram realizados anamnese, exame clínico e coleta de enxágüe bucal de cada paciente. A amostra de enxágüe bucal foi semeada em meios de cultura específicos para cada microrganismo e após período de incubação foram realizadas contagens de unidades formadoras de colônia (UFC), obtendo-se o número de UFC/mL. A partir dos isolados obtidos, foram realizadas provas de identificação a fim de caracterizar as espécies dos gêneros em estudo. As contagens de microrganismos foram comparadas entre os grupos LES e controle por ANOVA, Mann Whitney (5%). Contagens de microrganismos em indivíduos sob tratamento com fármacos imunossupressores ou não e atividade positiva...
Considering that patients with systemic erithematous lupus are treated with corticoids and immunossuppresive drugs, this condition may interfere in the presence of potentially opportunistic microorganisms in the oral cavity. The aim of this study was to evaluate the presence of Candida spp. staphylococci, enterobacteria and Pseudomonas spp. in the oral cavity of patients with systemic erithematous lupus (LES) comparing the results with control individuals. Forty patients aged 19-53 years with LES and under therapy for at least 60 days were selected. For the control group, 40 healthy individuals paired to the test group in relation to age, gender and oral conditions were selected. Diabetic and other systemic diseases patients, denture users and individuals under therapy with drugs that affect the oral conditions were not included. Clinical examination, anamnesis and oral rinses sampling were performed. Oral rinse samples were plated on specific culture media and after the period of incubation the number of colony forming units were counted, and the value of cfu/ml was obtained. The isolates were identified in order to obtain the species. The counts of microorganisms were compared between LES and control groups by ANOVA, Mann Whitney (5%). Also, counts of microorganisms in patients under treatment with immunossupressive drugs of not and positive or negative activity of the disease (SLEDAI) were compared. No significant differences in the counts of microorganisms between the studied groups were observed (yeasts, p= 0.55; staphylococci, p=0.24; enterobacteria/Pseudomonas spp., p=0.26). No differences in the counts of microorganisms were observed related to the clinical parameters tested. Higher prevalence of Candida albicans and Staphylococcus epidermidis... (Complete abstract click electronic access below)
Considering that patients with systemic erithematous lupus are treated with corticoids and immunossuppresive drugs, this condition may interfere in the presence of potentially opportunistic microorganisms in the oral cavity. The aim of this study was to evaluate the presence of Candida spp. staphylococci, enterobacteria and Pseudomonas spp. in the oral cavity of patients with systemic erithematous lupus (LES) comparing the results with control individuals. Forty patients aged 19-53 years with LES and under therapy for at least 60 days were selected. For the control group, 40 healthy individuals paired to the test group in relation to age, gender and oral conditions were selected. Diabetic and other systemic diseases patients, denture users and individuals under therapy with drugs that affect the oral conditions were not included. Clinical examination, anamnesis and oral rinses sampling were performed. Oral rinse samples were plated on specific culture media and after the period of incubation the number of colony forming units were counted, and the value of cfu/ml was obtained. The isolates were identified in order to obtain the species. The counts of microorganisms were compared between LES and control groups by ANOVA, Mann Whitney (5%). Also, counts of microorganisms in patients under treatment with immunossupressive drugs of not and positive or negative activity of the disease (SLEDAI) were compared. No significant differences in the counts of microorganisms between the studied groups were observed (yeasts, p= 0.55; staphylococci, p=0.24; enterobacteria/Pseudomonas spp., p=0.26). No differences in the counts of microorganisms were observed related to the clinical parameters tested. Higher prevalence of Candida albicans and Staphylococcus epidermidis... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Lupus eritematoso sistemico, Infecções oportunistas, Cavidade bucal - Superinfectantes, Systemic erithematous lupus - Oral cavity
Como citar
NAVAS, Edna Aparecida Ferraz de Araujo. Prevalência de microrganismos potencialmente superinfectantes na cavidade bucal de pacientes com Lúpus Eritematoso Sistêmico. 2009. 78 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Odontologia de São José dos Campos., 2009.