Determinação da concentração alveolar mínima(CAM) de sevofluorano em filhotes de cães (neonatos e pediátricos)
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Data
2008-02-21
Autores
Gabas, Daniela Tozadore [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
Há controvérsia na literatura sobre a determinação do período exato que corresponde à classificação dos pacientes caninos em neonatos ou pediátricos. Contudo, sabe-se que até 6 semanas de idade estes animais apresentam imaturidade do sistema respiratório, cardiovascular, sistema nervoso central, hepático e renal. Tal imaturidade dos sistemas pode interferir na disponibilidade dos fármacos e na resposta destes à anestesia. Alguns fatores influenciam diretamente a concentração alveolar mínima (CAM) dos anestésicos inalatórios sendo a idade um destes. Há escassa literatura a respeito da influencia da idade na CAM dos anestésicos inalatórios. Desta maneira, este trabalho tem o objetivo de determinar a concentração alveolar mínima (CAM) do sevofluorano em cães jovens nas diferentes faixas etárias pré-determinadas pelos pesquisadores. Foram utilizados oito filhotes de cães, da raça Retriever do Labrador, submetidos à anestesia inalatória com sevofluorano aos 30, 45, 60 e 90 (± 2) dias de idade. A monitoração foi composta de freqüência cardíaca, freqüência respiratória, pressão arterial sistólica não-invasiva, oximetria de pulso, hemogasometria arterial e temperatura retal, concentração de sevofluorano (ETsev) e dióxido de carbono (ETco2) no final da expiração. A ETsev ao final da expiração foi mantida em 3% por no mínimo 15 minutos para a realização do estímulo supramáximo doloroso e determinação da CAM que constitiu-se em pinçamento de cauda durante 60 segundos ou menos, caso a resposta fosse positiva. Quando a resposta ao primeiro estímulo fosse negativa, a concentração de sevofluorano foi diminuída em 0,2% em relação a concentração inicial (3%) e o estímulo foi repetido após 15 minutos, para possibilitar a estabilização do circuito. Se, inicialmente...
In the literature we researched certain difficulty could be noted in the determination of the exact period for the classification of canine patients in neonates and pediatrics. However, it is anyway known that until 6 weeks of age these animals have very immature respiratory, cardiovascular, central nervous system, hepatic, and renal systems. Such immaturity of their organic systems may interfere in the drug disponibility and reaction, as well as in their reaction to the anaesthesic agent. Some factors interfere directly in the minimum alveolar concentration (MAC) of inhalant anaesthesics, and age is certainly one of them. There is a shortage of studies about age influence over MAC of inhalant anaesthesical agents. So, this work is aimed to determine the minimum alveolar concentration (MAC) of sevoflurane in young dogs, divided in different age groups by researchers. Eight Labrador Retriever baby dogs underwent inhalant anaesthesia with sevoflurane in the ages of 30, 45, 60 and 90 (+/-2) days. The checkup included heart and breath frequencies, non-invasive systolical blood pressure pulse oximetry, arterial blood gas and rectal temperature, sevoflurane (ETsev) and carbon dioxide (ETCO2) concentrations in the end of the expiration. ETsev in the end of expiration was kept at 3% for at least 15 minutes for the accomplishment of the pain stimulus and MAC determination. For that, dogs were stimulated with tail clamping during 60 seconds or less, whether reaction were positive. When the reaction to the first stimulation were negative, sevoflurane concentration was decreased in 80% of its initial concentration (1.5 MAC), as well as the stimulus was repeated after 15 minutes, in order to stabilise the circuit. Whether in the beginning the answer were positive, the anaesthesic concentration was then increased in 20% and after 15 minutes a new stimulation was tried. This scheming was repeated as many times as it was necessary to achieve the negative.
In the literature we researched certain difficulty could be noted in the determination of the exact period for the classification of canine patients in neonates and pediatrics. However, it is anyway known that until 6 weeks of age these animals have very immature respiratory, cardiovascular, central nervous system, hepatic, and renal systems. Such immaturity of their organic systems may interfere in the drug disponibility and reaction, as well as in their reaction to the anaesthesic agent. Some factors interfere directly in the minimum alveolar concentration (MAC) of inhalant anaesthesics, and age is certainly one of them. There is a shortage of studies about age influence over MAC of inhalant anaesthesical agents. So, this work is aimed to determine the minimum alveolar concentration (MAC) of sevoflurane in young dogs, divided in different age groups by researchers. Eight Labrador Retriever baby dogs underwent inhalant anaesthesia with sevoflurane in the ages of 30, 45, 60 and 90 (+/-2) days. The checkup included heart and breath frequencies, non-invasive systolical blood pressure pulse oximetry, arterial blood gas and rectal temperature, sevoflurane (ETsev) and carbon dioxide (ETCO2) concentrations in the end of the expiration. ETsev in the end of expiration was kept at 3% for at least 15 minutes for the accomplishment of the pain stimulus and MAC determination. For that, dogs were stimulated with tail clamping during 60 seconds or less, whether reaction were positive. When the reaction to the first stimulation were negative, sevoflurane concentration was decreased in 80% of its initial concentration (1.5 MAC), as well as the stimulus was repeated after 15 minutes, in order to stabilise the circuit. Whether in the beginning the answer were positive, the anaesthesic concentration was then increased in 20% and after 15 minutes a new stimulation was tried. This scheming was repeated as many times as it was necessary to achieve the negative.
Descrição
Palavras-chave
Anestesia, Anestésicos inalatórios, Inhalant anaesthesical agents
Como citar
GABAS, Daniela Tozadore. Determinação da concentração alveolar mínima(CAM) de sevofluorano em filhotes de cães (neonatos e pediátricos). 2008. 54 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2008.