Anti dermatophytic therapy: prospects for the discovery of new drugs from natural products
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Data
2013-12-01
Autores
Soares, Luciana Arantes [UNESP]
Sardi, Janaína De Cássia Orlandi [UNESP]
Gullo, Fernanda Patrícia [UNESP]
Pitangui, Nayla De Souza [UNESP]
Scorzoni, Liliana [UNESP]
Leite, Fernanda Sangalli [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
Almeida, Ana Marisa Fusco [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Microbiologia
Resumo
Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments.
Descrição
Palavras-chave
dermatophytes, filamentous fungi, natural products, synthetic product
Como citar
Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 44, n. 4, p. 1035-1041, 2013.