Interaction of Curcumin with Manganese May Compromise Metal and Neurotransmitter Homeostasis in the Hippocampus of Young Mice
Nenhuma Miniatura disponível
Data
2014-06-01
Autores
Schmitz, Ariana Ern
Oliveira, Paulo Alexandre de
Souza, Luiz F. de
Humberto da Silva, Danilo Gruenig [UNESP]
Danielski, Samara
Santos, Danubia Bonfanti
Almeida, Eduardo Alves de [UNESP]
Prediger, Rui Daniel
Fisher, Andrew
Farina, Marcelo
Título da Revista
ISSN da Revista
Título de Volume
Editor
Humana Press Inc
Resumo
Manganese (Mn) exposure is related to industrial activities, where absorption by inhalation has high relevance. Manganism, a syndrome caused as a result of excessive accumulation of Mn in the central nervous system, has numerous symptoms similar to those seen in idiopathic Parkinson disease (IPD). Some of these symptoms, such as learning, memory, sensorial, and neurochemical changes, appear before the onset of motor deficits in both manganism and IPD. The aim of this study was to evaluate the possible neuroprotective effects of curcumin against behavioral deficits induced by Mn toxicity in young (2 months old) Swiss mice. We evaluated the effect of chronic inhalation of a Mn mixture [Mn(OAc)(3) and MnCl2 (20:40 mM)], 1 h/session, three times a week, over a 14-week period on behavioral and neurochemical parameters. Curcumin was supplemented in the diet (500 or 1,500 ppm in food pellets). The Mn disrupted the motor performance evaluated in the single-pellet reach task, as well as the short- and long-term spatial memory evaluated in the step-down inhibitory avoidance task. Surprisingly, curcumin also produced similar deleterious effects in such behavioral tests. Moreover, the association of Mn plus curcumin significantly increased the levels of Mn and iron, and decreased the levels of dopamine and serotonin in the hippocampus. These alterations were not observed in the striatum. In conclusion, the current Mn treatment protocol resulted in mild deficits in motor and memory functions, resembling the early phases of IPD. Additionally, curcumin showed no beneficial effects against Mn-induced disruption of hippocampal metal and neurotransmitter homeostasis.
Descrição
Palavras-chave
Manganese, Curcumin, Idiopathic Parkinson disease, Memory, Motor performance
Como citar
Biological Trace Element Research. Totowa: Humana Press Inc, v. 158, n. 3, p. 399-409, 2014.