Epidemiological Report on the Treatment of Patients with Gestational Trophoblastic Disease in 10 Brazilian Referral Centers Results After 12 Years Since International FIGO 2000 Consensus
Nenhuma Miniatura disponível
Data
2014-05-01
Autores
Braga, Antonio
Hartmann Uberti, Elza Maria
Fajardo, Maria do Carmo
Viggiano, Mauricio
Sun, Sue Yazaki
Grillo, Bruno Maurizio
Padilha, Sergio Lunardon
Andrade, Jurandyr Moreira de
Souza, Christiani Bisinoto de
Madi, Jose Mauro
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sci Printers & Publ Inc
Resumo
OBJECTIVE: To evaluate treatment of Brazilian patients with gestational trophoblastic disease (GTD).STUDY DESIGN: A retrospective cohort study with analysis of medical reports performed in 10 Brazilian referral centers from January 2000 to December 2011.RESULTS: Of 5,250 patients 3 died (0.06%) at the time of uterine evacuation. Spontaneous remission of GTD (group G1) was observed in 4,103 cases, and 1,144 (21.8%) progressed to gestational trophoblastic neoplasia (GTN) (G2). In G1 2,716 (66.2%) had complete hydatidiform mole (HM) and 1,210, partial HM (29.5%); 3,772 patients (92.7%) recovered as noted in December 2012. In G2, of 1,118 patients treated, initial histopathological results of previous gestation were complete HM (77.5% [n = 886]), partial HM (8.8% [n = 100]), and choriocarcinoma (8.0% [n = 92]); 930 (81.3%) were low-risk, 200 (17.5%) were high-risk GTN, and 14 had placental site trophoblastic tumor (PSTT) (1.2%); cure was achieved in 1,078 cases (96.4%), but 26 patients (2.3%) died (4 low-risk [0.4%], 19 high-risk [9.5%], and 3 PSTT [21.4%]).CONCLUSION: The highest death rates were due to high-risk GTN and PSTT. Patients with molar pregnancy should be referred to a referral center for an early diagnosis and prompt treatment of GTN in order to reduce the morbidity and mortality found in advanced stages.
Descrição
Palavras-chave
epidemiology, gestational trophoblastic disease, gestational trophoblastic neoplasia, hydatidiform mole, placental site trophoblastic tumor
Como citar
Journal of Reproductive Medicine. St Louis: Sci Printers & Publ Inc, v. 59, n. 5-6, p. 241-247, 2014.