Biologically Active Eremophilane-Type Sesquiterpenes from Camarops sp., an Endophytic Fungus Isolated from Alibertia macrophylla
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2014-03-01
Autores
Gubiani, Juliana R. [UNESP]
Zeraik, Maria L. [UNESP]
Oliveira, Camila M.
Ximenes, Valdecir F. [UNESP]
Nogueira, Claudio R. [UNESP]
Fonseca, Luiz M. [UNESP]
Silva, Dulce Helena Siqueira [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
Araújo, Angela Regina [UNESP]
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Amer Chemical Soc
Resumo
Two new eremophilane-type sesquiterpenes, xylarenones F (3) and G (4), have been isolated from solid substrate cultures of a Camarops sp. endophytic fungus isolated from Alibertia macrophylla, together with the known compounds xylarenones C (1) and D (2). The structures and relative configurations of 1-4 were elucidated by extensive NMR and HRESIMS spectroscopic analysis. Due to their effects on the respiratory burst of neutrophils, which included inhibition of the reactive oxygen species production, these sesquiterpenes exhibited potential anti-inflammatory and antioxidant properties.
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Journal Of Natural Products. Washington: Amer Chemical Soc, v. 77, n. 3, p. 668-672, 2014.