Solubility and release modulation effect of sulfamerazine ternary complexes with cyclodextrins and meglumine

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Data

2014-11-01

Autores

Aloisio, Carolina [UNESP]
Oliveira, Anselmo Gomes de [UNESP]
Longhi, Marcela

Título da Revista

ISSN da Revista

Título de Volume

Editor

Elsevier B.V.

Resumo

This study investigated the effect on solubility and release of ternary complexes of sulfamerazine (SMR) with beta-(beta CD), methyl-(M beta CD) and hydroxypropyl-P-cyclodextrin (HP beta CD) using meglumine (MEG) as the ternary component. The combination of MEG with M beta CD resulted the best approach, with an increased effect (29-fold) of the aqueous solubility of SMR. The mode of inclusion was supported by 2D NMR, which indicated that real ternary complexes were formed between SMR, MEG and M beta CD or HP beta CD. Solid state analysis was performed using Fourier-transform infrared spectroscopy (FT IR), differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD), which demonstrated that different interactions occurred among SMR, MEG and M beta CD or HP beta CD in the ternary lyophilized systems. The ternary complexes with beta CD and M beta CD produced an additional retention effect on the release of SMR compared to the corresponding binary complexes, implying that they were clearly superior in terms of solubility and release modulation. (C) 2014 Elsevier B.V. All rights reserved.

Descrição

Palavras-chave

Sulfamerazine, Cyclodextrin, Ternary complex, Solubility, In vitro-release

Como citar

Journal Of Pharmaceutical And Biomedical Analysis. Amsterdam: Elsevier Science Bv, v. 100, p. 64-73, 2014.