Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi
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Data
2014-01-01
Autores
Alves de Paula e Silva, Ana Carolina [UNESP]
Costa-Orlandi, Caroline Barcelos [UNESP]
Gullo, Fernanda Patricia [UNESP]
Sangalli-Leite, Fernanda [UNESP]
Oliveira, Haroldo Cesar de [UNESP]
Silva, Julhiany de Fatima da [UNESP]
Scorzoni, Liliana [UNESP]
Pitangui, Nayla de Souza [UNESP]
Rossi, Suelen Andrea [UNESP]
Benaducci, Tatiane [UNESP]
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Hindawi Publishing Corporation
Resumo
This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI) documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.
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Evidence-based Complementary And Alternative Medicine. New York: Hindawi Publishing Corporation, 8 p., 2014.