Oxidative Stress in Maternal Blood and Placenta From Mild Diabetic Rats
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Data
2014-08-01
Autores
Spada, Ana Paula Machado [UNESP]
Damasceno, Debora Cristina [UNESP]
Sinzato, Yuri Karen [UNESP]
Campos, Kleber Eduardo de [UNESP]
Faria, Priscila Afonso
Dallaqua, Bruna [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Rodrigues, Tiago
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Editor
Sage Publications Inc
Resumo
The aim of the present study was at evaluating the effects of oxidative stress in blood and placenta of mild diabetic Wistar rats. At birth, Wistar rats received citrate buffer (nondiabetic group, n = 15) and another group received streptozotocin (100 mg/kg, subcutaneous) to induce mild diabetes (diabetic, n = 15). The glycemia of these pregnant adult female rats were evaluated at days 0, 7, 14, and 21 of pregnancy, and at term pregnancy, the blood and placental samples were collected for oxidative stress measurements. The mild diabetes caused glycemia superior to 120 mg/dL during pregnancy, increased superoxide dismutase, glutathione peroxidase, glutathione reductase activities, and malondialdehyde levels in the blood, and catalase activity in the placenta. Thus, mild diabetes increased activities of antioxidant substances aiming at defending against the exacerbated oxidative stress but were not enough. The placenta also answered to diabetic milieu and increased antioxidant defense, showing that even a mild hyperglycemia was enough to cause placental and maternal blood changes.
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Palavras-chave
streptozotocin, rats, diabetes, oxidative stress, placenta
Como citar
Reproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 21, n. 8, p. 973-977, 2014.