Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis

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Data

2008-10-01

Autores

Spinnato, Joseph A.
Freire, Salvio
Pinto e Silva, Joao Luiz
Rudge, Marilza Vieira Cunha [UNESP]
Martins-Costa, Sergio
Koch, Matthew A.
Goco, Norman
Santos, Cleide de Barros
Cecatti, Jose Guilherme
Costa, Roberto [UNESP]

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Editor

Mosby-elsevier

Resumo

OBJECTIVE: The purpose of this study was to determine if antioxidant supplementation during pregnancy reduces the incidence of premature rupture of the membranes (PROM).STUDY DESIGN: A placebo-controlled, double-blind trial was conducted. PROM and preterm PROM (PPROM) were planned secondary outcomes of the trial. Women between 12(0/7) and 19(6/7) weeks of gestation and diagnosed to have chronic hypertension or a prior history of preeclampsia were randomized to daily treatment with both vitamin C (1000 mg) and E (400 IU) or placebo.RESULTS: Outcome data for PROM were available for 697 of 739 patients. The rates of PROM (37/349 [10.6%] vs 19/348 [5.5%]; adjusted risk ratio [RR] 1.89 [95.42% CI, 1.11-3.23]; P = .015), and PPROM (16/349 [4.6%] vs 6/348 [1.7%]; RR 2.68 [1.07-6.71]; P = .025) were increased in the antioxidant group.CONCLUSION: Contrary to expectations, vitamins C and E supplementation in this dose combination may be associated with an increased risk of PROM and PPROM.

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Palavras-chave

antioxidants, premature rupture of the membranes, prematurity, prevention, vitamin C, vitamin E

Como citar

American Journal of Obstetrics and Gynecology. New York: Mosby-elsevier, v. 199, n. 4, p. 8, 2008.