Promotion of hepatocarcinogenesis by hexachlorobenzene in energy-restricted rats
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Data
2000-04-28
Autores
Kishima, M. O.
Barbisan, Luis Fernando [UNESP]
Estevao, D.
Rodrigues, MAM
de Camargo, JLV
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B.V.
Resumo
The interaction between dietary energy restriction and low dose of the fungicide hexachlorobenzene (HCB) was evaluated in a rat liver medium-term bioassay for carcinogenesis. Male Wistar rats were fed a control or a 50% energy-restricted diet, both added or not with 50 ppm HCB, for 6 weeks. HCB exposure or energy restriction separately did not exert any influence on the development of glutathione S-transferase placental form (GST-P+) foci of hepatocytes. Simultaneous HCB exposure and energy restriction induced a significant increase in liver centrilobular hypertrophy and GST-P+ foci development. Our findings suggest that energy restriction increases liver response to low dose of HCB, unmasking the promoting potential of this fungicide. (C) 2000 Elsevier B.V. Ireland Ltd. All rights reserved.
Descrição
Palavras-chave
energy restriction, carcinogenesis, hexachlorobenzene, medium-term bioassay, liver GST-P-positive foci
Como citar
Cancer Letters. Clare: Elsevier Sci Ireland Ltd, v. 152, n. 1, p. 37-44, 2000.