Nitric Oxide and Nitroxyl Products from the Reaction of L-Cysteine with trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3)
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Data
2015-02-01
Autores
Melo Pereira, José Clayston [UNESP]
Souza, Maykon Lima
Franco, Douglas Wagner
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Editor
Wiley-Blackwell
Resumo
The reaction between the trans-[RuNO(NH3)(4)P(OEt)(3)](PF6)(3) and L-cysteine (RS-) was studied over a pH range of 2.0-7.4. In this reaction, the concentrations of NO and HNO produced varied as a function of the pH of the solution. The first step of this reaction proceeded quickly [k(1) = (3.5 +/- 0.3)x10(3) M-1 s(-1), pH = 3.5, 25 degrees C] and resulted in the formation of trans-[Ru(NH3)(4)P(OEt)(3)N(O)SR](2+), which dissociated to yield trans-[Ru(NH3)(4)P(OEt)(3)NO](2+) and RS. However, trans-[Ru(NH3)(4)P(OEt)(3)N(O)SR](n-1) can react with a second L-cysteine, yielding trans-[Ru(NH3)(4)P(OEt)(3)N(O)(SR)(2)](+) [k(2) = (3.6 +/- 0.1) M(-1)s(-1), pH = 3.5, 25 degrees C]. Therefore, the trans-[Ru(NH3)(4)P(OEt)(3)NO](2+) species released NO and the trans-[Ru(NH3)(4)P(OEt)(3)N(O)(SR)(2)](n-2) species released HNO.
Descrição
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Nitric oxide, Nitroxyl, Nitrogen oxides, Ruthenium, Kinetics, Medicinal chemistry
Como citar
European Journal Of Inorganic Chemistry. Weinheim: Wiley-v C H Verlag Gmbh, v. 2015, n. 6, p. 1005-1011, 2015.