A critical review of the properties of fusidic acid and the analytical methods for its determination
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Data
2015
Autores
Curbete, Mariane Machado [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Taylor and Francis Online
Resumo
Fusidic acid, an antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids, but has no corticosteroid effects. It is indicated for the treatment of infections caused by methicillin-resistant Staphylococcus aureus strains. The aim of this study was to search for the properties of fusidic acid published so far in the literature, as well as the methods developed for its determination in biological samples and pharmaceutical formulations. From the findings, we can conclude that fusidic acid has been used for decades and is indicated for the treatment of serious infections caused by Gram-positive microorganisms to this day. Furthermore, it is a hypoallergenic agent, has low toxicity, shows low resistance, and has no cross-resistance with other clinically used antibiotics. The analytical method of high-performance liquid chromatography has been widely used, since it can reduce the cost and time of analysis, making it more viable for routine quality control in the pharmaceutical industry.
Descrição
Palavras-chave
Fusidic acid, Analytical methods, Quality control, Review
Como citar
Critical Reviews in Analytical Chemistry/Crc, 2015.