Current advances in antitubercular drug discovery: potent prototypes and new targets
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Data
2015
Autores
Fernandes, Guilherme Felipe dos Santos [UNESP]
Jornada, Daniela Hartmann [UNESP]
Souza, Paula Carolina de [UNESP]
Chin, Chung Man [UNESP]
Pavan, Fernando Rogerio [UNESP]
Santos, Jean Leandro dos [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Bentham Science Publishers
Resumo
Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to substantially reduce the number of cases in the coming years; however, the increased number of multidrug-resistant (MDR) and extremely drug-resistant (XDR) forms of the bacterium and the lack of treatment for latent tuberculosis are challenges to be overcome. In this review, we have identified the most potent compounds described in the literature during recent years with MIC values < 7 µM, low toxicity and a high selective index. In addition, emerging targets in MTB are presented to provide new perspectives for the discovery of new antitubercular drugs. This review aims to summarize the current advances in and promote insights into antitubercular drug discovery.
Descrição
Palavras-chave
Antitubercular drugs, Drug discovery, Mycobacterium tuberculosis, Resistant tuberculosis, Tuberculosis, Tuberculosis targets
Como citar
Current Medicinal Chemistry, v. 22, n. 27, p. 3133-3161, 2015.