High-intensity resistance training attenuates dexamethasone-induced muscle atrophy
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Data
2015-09-10
Autores
Krug, André L. O. [UNESP]
Macedo, Anderson G. [UNESP]
Zago, Anderson S. [UNESP]
Rush, James W. E.
Santos, Carlos F.
Amaral, Sandra L. [UNESP]
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Editor
Wiley-Blackwell
Resumo
We investigated the effects of high-intensity resistance training (RT) on dexamethasone (DEX) induced muscle atrophy in flexor hallucis longus (FHL), tibialis anterior (TA), and soleus (SOL) muscles. Rats underwent either high-intensity RT or were kept sedentary. In the last 10 days they received either DEX (0.5 mg/kg/d, i.p.) or saline. DEX reduced body weight (-21%), food intake (-28%), FHL and TA muscle mass (-20% and -18%), and increased in muscle-specific ring finger 1 (MuRF-1) protein level (+37% and +45.5%). RT attenuated FHL muscle atrophy by a combination of a low increase in MuRF-1 protein level (-3.5%) and significant increases in mammalian target of rapamycin (mTOR) (+63%) and p70S6K (+46% and +49% for Ctrl and DEX) protein levels. The data show that RT attenuated DEX-induced muscle atrophy by a combination of increases in mTOR and p70S6K protein level and a low increase in MuRF-1 protein level. This article is protected by copyright. All rights reserved.
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Palavras-chave
Glucocorticoids, Ladder climbing, Muscle atrophy, Resistance training, Skeletal muscle
Como citar
Muscle & Nerve, p. 1-28, 2015.