Stability, purification, and applications of bromelain: a review
Nenhuma Miniatura disponível
Data
2015-10-30
Autores
Novaes, Letícia Celia de Lencastre
Jozala, Angela Faustino
Lopes, André Moreni
Santos-Ebinuma, Valéria de Carvalho [UNESP]
Mazzola, Priscila Gava
Pessoa Junior, Adalberto
Título da Revista
ISSN da Revista
Título de Volume
Editor
American Institute of Chemical Engineers
Resumo
Bromelain is a cysteine protease found in pineapple tissue. Due to its anti-inflammatory and anti-cancer activities, as well as its ability to induce apoptotic cell death, bromelain has proved useful in several therapeutic areas. The market for this protease is growing, and several studies exploring various properties of this molecule have been reported. This review aims to compile this data, and summarize the main findings on bromelain in the literature to date. The physicochemical properties and stability of bromelain under different conditions are discussed. Several studies on the purification of bromelain from crude extracts using a wide range of techniques such as liquid-liquid extractions by aqueous two-phase system, ultrafiltration, precipitation, and chromatography, have been reported. Finally, the various applications of bromelain are presented. This review therefore covers the main properties of bromelain, aiming to provide an up-to-date compilation of the data reported on this enzyme.
Descrição
Palavras-chave
Bromelain, Anti-inflammatory, Downstream processes, Pineapple, Protease, Purification
Como citar
Biotechnology Progress, 2015.