Bisphenol-A promotes antiproliferative effects during neonatal prostate development in male and female gerbils
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Data
2015-10-31
Autores
Lima, Rodrigo Fernandes de
Rodriguez, Daniel Andrés Osório
Campos, Mônica Souza [UNESP]
Biancardi, Manoel Francisco
Santos, Iana Figueiredo Ferreira Roriz dos
Oliveira, Wendyson Duarte de
Cavasin, Gláucia Maria
Marques, Mara Rubia
Taboga, Sebastião Roberto [UNESP]
Alcantara dos Santos, Fernanda Cristina
Título da Revista
ISSN da Revista
Título de Volume
Editor
Elsevier B. V.
Resumo
The aim of this study was to evaluate the development of male and female neonatal gerbil prostate under normal conditions and exposed to bisphenol-A (BPA). Normal postnatal development of the female gerbil prostate occurs earlier than and is morphologically distinct from that occurring in males. In BPA-exposed PND8 gerbils, we have not observed evidence of alterations in the ductal branching in either gender. However, the exposure to BPA alters the immunolabeling pattern of AR, ERα, and PCNA. In males, the exposure to high dosages of BPA resulted in a decrease in the proliferative status of the developing ventral prostate. In females, both high and low dosages were sufficient to decrease the proliferation of paraurethral buds in the branching process by more than 50%. Therefore, the obtained data indicate that BPA promotes antiproliferative effects during the neonatal development of the gerbil prostate, with more sensitivity to this endocrine disruptor in females.
Descrição
Palavras-chave
Ar antagonists, Endocrine-disrupting chemicals, Gerbil, Prostatic morphogenesis
Como citar
Reproductive Toxicology (elmsford, N.y.), v. 58, p. 238–245, 2015.