Anti-inflammatory drug design by molecular hybridization approach
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Data
2011
Autores
Bosquesi, Priscila Longhin [UNESP]
Melo, Tais Regina Ferreira [UNESP]
Vizioli, Ednir de Oliveira [UNESP]
Santos, Jean Leandro dos [UNESP]
Chung, Man Chin [UNESP]
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Resumo
The design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach.
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Palavras-chave
Anti-inflammatory, Hybridization, Multiple-ligands, Mutual prodrug
Como citar
Pharmaceuticals, v. 4, p. 1450-1474, 2011.