Validation of cefazolin sodium by UV-spectrophotometric method
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Data
2013
Autores
Pedroso, Tahisa Marcela [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Scientific and Academic Publishing
Resumo
A simple, fast and reproducible UV Spectrophotometric method was developed and validated for quantification of cefazolin sodium in pharmaceutical form powder for injectable solution, the method proved effective, easy applicability, low cost, besides it does not generate toxic wastes to the operator and the environment, corroborating with the routine analysis of quality control to ensure the therapeutic efficacy of the drug already marketed. The method presented being capable to detect and quantify the drug obtaining satisfactory results regarding specificity, precision, accuracy and robustness, linear range of 8 to 28 µg/mL, showing correlation coefficient of 0.9999 when analyzed in the wavelenght λ=270 nm spectrophotometer.
Descrição
Palavras-chave
Cefazolin sodium, Cephalosporin, Analytical method, Quantitative analysis, Quality control
Como citar
Physical Chemistry, v. 3, n. 1, p. 11-20, 2013.