Effect of low-dose combined oral contraceptives on bone mineral density in adolescents: a 1-year follow-up
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2013
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Biason, Talita Poli [UNESP]
Moretto, Maria Regina [UNESP]
Rezende, Cristina Fortes [UNESP]
Kurokawa, Cilmery Suemi [UNESP]
Teixeira, Altamir [UNESP]
Nunes, Helio [UNESP]
Santanna, Maria José
Coates, Veronica
Goldberg, Tamara Beres Lederer [UNESP]
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Purpose: To assess the bone mineral density (BMD) and bone mineral content (BMC) of female adolescents in use of standard low-dose combined oral contraceptives (COC) (EE 20 mcg/ Desogestrel 150 mcg) for a one-year period and to compare results against healthy controls matched for age and gender not in use of COC. Methods: A prospective, longitudinal study was conducted.Fifty adolescents, 12 to 20 years of age, were divided into a COC user group (n 35) and a control group (n 15) and submitted to a Bone Densitometry scan using dual-energy X-ray absorptiometry (DXA) at study inclusion and again at 12-month follow-up. Results: Results showed no statistically significant differences between the COC user and control groups at the initial moment. However, at 12-month follow-up, COC users showed negative mean percentage variation between initial and follow-up values for lumbar spine BMD and BMC of -1.09% and -1.58%, respectively, whereas controls had positive variations of +12.44% and +15.87%, respectively. Thus, the adolescents in use of COC showed a loss, albeit slight, in bone mass whereas the control group showed an increase. Conclusions: The low dose COC assessed (EE 20 mcg/Desogestrel 150 mcg) appeared to negatively affect the process of bone mass acquisition which occurs during adolescence.
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Journal of Adolescent Health, v. 52, n. 2, p. 92-92, 2013.