Taenia solium DNA is present in the cerebrospinal fluid of neurocysticercosis patients and can be used for diagnosis
Nenhuma Miniatura disponível
Data
2006-08-01
Autores
Almeida, Carolina R.
Ojopi, Elida P.
Nunes, Caris Maroni [UNESP]
Machado, Luis R.
Takayanagui, Osvaldo M.
Livramento, Jose A.
Abraham, Ronaldo
Gattaz, Wagner F.
Vaz, Adelaide J.
Dias-Neto, Emmanuel
Título da Revista
ISSN da Revista
Título de Volume
Editor
Dr Dietrich Steinkopff Verlag
Resumo
Neurocysticercosis is the most frequent parasitic infection of the CNS and the main cause of acquired epilepsy worldwide. Seizures are the most common symptoms of the disease, together with headache, involuntary movements, psychosis and a global mental deterioration. Absolute diagnostic criteria include the identification of cysticerci, with scolex, in the brain by MRI imaging. We demonstrate here, for the first time, that T. solium DNA is present in the cerebrospinal fluid of patients. The PCR amplification of the parasite DNA in the CSF enabled the correct identification of 29/30 cases (96.7 %). The PCR diagnosis of parasite DNA in the CSF may be a strong support for the diagnosis of neurocysticercosis.
Descrição
Palavras-chave
PCR, CSF, neurocysticercosis, Taenia solium, liquor
Como citar
European Archives of Psychiatry and Clinical Neuroscience. Darmstadt: Dr Dietrich Steinkopff Verlag, v. 256, n. 5, p. 307-310, 2006.