Funcionalização da liga Ti15Zr15Mo após crescimento de nanotubos de TiO2 com recobrimento de quitosana, ácido hialurônico e partículas de ZnO para aplicações biomédicas
Carregando...
Arquivos
Data
2018-03-06
Autores
Konatu, Reginaldo Toshihiro [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Resumo
O presente trabalho tem como objetivo a obtenção de revestimentos poliméricos bactericidas formados por ácido hialurônico/quitosana/ZnO na superfície da liga Ti15Zr15Mo após crescimento de nanotubos de TiO2 empregando oxidação anódica. A liga Ti15Zr15Mo foi processada em forno a arco voltaico com atmosfera controlada e tratados termicamente. Os nanotubos de TiO2 foram obtidos por meio de oxidação anódica. Para obtenção dos revestimentos, as amostras foram recobertas com camadas de ácido hialurônico/quitosana/ZnO. As superfícies foram avaliadas empregando microscopia eletrônica de varredura (MEV), analise por difração de raios-X (DRX), espectroscopia de fotoelétrons excitados por raios-X (XPS) e ângulo de contato. A condição ideal para obtenção dos nanotubos ordenados de TiO2 na superfície da liga foi 30V, eletrólito formado por glicerol, água deionizada (1:1 em volume) e fluoreto de amônio (2,7 g/L) e tempo de 24 horas. Para esses parâmetros, os nanotubos formados apresentaram diâmetro médio de 130 nm e espessura de 1290 nm. O revestimento polimérico escolhido foi de 2 bicamadas de ácido hialurônico/quitosana contendo partículas de ZnO. Os estudos in vitro realizados para avaliar adesão bacteriana de Staphylococcus aureus mostraram que não houve diferença significativa entre as amostras com e sem recobrimento.
Nowadays the development of new materials for biomedical application has become of extreme importance due to the need of new materials with excellent mechanical properties, physicochemical and biocompatibility for use in the manufacture of biomedical devices. In addition to the material presenting the necessary bulk properties, it is of utmost importance that they present a response from the host to the implant. For this, the surface of the material must have characteristics that can be obtained with superficial treatments. This work aims at the analysis of the surface of nanotubes grown on the Ti15zr15Mo alloy functionalized with thin film of hyaluronic acid, chitosan and ZnO nanoparticles. The surface was analyzed by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and contact angle. The nanotubes formed had a mean diameter of 130 nm and a thickness of 1290 nm. The coating with the polymeric bilayers, with a number of more than 4 bilayers, closed the nanotubes and increased the contact angle, being used 2 biacamadas for the incorporation of ZnO. The concentration of the ZnO solution was very low for incorporation and bactericidal effect.
Nowadays the development of new materials for biomedical application has become of extreme importance due to the need of new materials with excellent mechanical properties, physicochemical and biocompatibility for use in the manufacture of biomedical devices. In addition to the material presenting the necessary bulk properties, it is of utmost importance that they present a response from the host to the implant. For this, the surface of the material must have characteristics that can be obtained with superficial treatments. This work aims at the analysis of the surface of nanotubes grown on the Ti15zr15Mo alloy functionalized with thin film of hyaluronic acid, chitosan and ZnO nanoparticles. The surface was analyzed by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and contact angle. The nanotubes formed had a mean diameter of 130 nm and a thickness of 1290 nm. The coating with the polymeric bilayers, with a number of more than 4 bilayers, closed the nanotubes and increased the contact angle, being used 2 biacamadas for the incorporation of ZnO. The concentration of the ZnO solution was very low for incorporation and bactericidal effect.
Descrição
Palavras-chave
Biomateriais, Funcionalização, Quitosana, Particulas de ZnO, Ligas de titânio, Biomaterials, Functionalization, Chitosan, ZnO Particles, Titanium alloys