Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina
Carregando...
Data
2008-01-01
Autores
Grillo, Renato [UNESP]
Melo, Nathalie F. S. de [UNESP]
Fraceto, Leonardo Fernandes [UNESP]
Brito, Charles L.
Trossini, Gustavo H. G.
Menezes, Carla M. S.
Ferreira, Elizabeth Igne
Moraes, Carolina Morales
Título da Revista
ISSN da Revista
Título de Volume
Editor
Sociedade Brasileira de Química
Resumo
Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.
Descrição
Palavras-chave
hydroxymethylnitrofurazone, cyclodextrin, inclusion complex
Como citar
Química Nova. Sociedade Brasileira de Química, v. 31, n. 2, p. 290-295, 2008.