Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats
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Data
2016-07-07
Autores
Matos, Juliana Fernandes [UNESP]
Americo, Madileine Francely
Sinzato, Yuri Karen [UNESP]
Volpato, Gustavo Tadeu
Cora, Luciana Aparecida
Freitas Calabresi, Marcos Felipe [UNESP]
Oliveira, Ricardo Brandt
Damasceno, Debora Cristina [UNESP]
Arruda Miranda, Jose Ricardo [UNESP]
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Editor
Baishideng Publishing Group Inc
Resumo
AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant (estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats (n = 23) were randomly divided into (1) non-pregnant, (contractility, n = 6; transit, n = 6); and (2) pregnant (contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry (ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions (3.90 +/- 0.42 cpm and 3.60 +/- 0.36 cpm vs 4.33 +/- 0.25 cpm) and gastric emptying (168 +/- 17 min and 165 +/- 15 min vs 113 +/- 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control (54.23 +/- 15.14 ng/mL and 129.96 +/- 30.52 ng/mL vs 13.25 +/- 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0 (44.3 +/- 15.18 pg/mL vs 24.96 +/- 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying.
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Palavras-chave
Reproductive physiological process, Sex hormones, Gastrointestinal motility, Magnetic fields, Gastric emptying
Como citar
World Journal Of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 22, n. 25, p. 5761-5768, 2016.