Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model
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Data
2017-02-28
Autores
Morais Lima, Gedson Rodrigues de
Frota Machado, Flavia Danniele
Lucena Perico, Larissa [UNESP]
Meira de Faria, Felipe
Luiz-Ferreira, Anderson
Souza Brito, Alba Regina Monteiro
Helena Pellizzon, Cludia [UNESP]
Akiko Hiruma-Lima, Claudia [UNESP]
Fechine Tavares, Josean
Barbosa Filho, Jose Maria
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Editor
Baishideng Publishing Group Inc
Resumo
AIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract (EtOHE) and hexane phase (HexP) obtained from the leaves of Combretum duarteanum (Cd). METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-EtOHE and Cd-HexP caused significant reductions in macroscopic lesion scores and ulcerative lesion areas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-alpha and IL-1 beta. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease.
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Palavras-chave
Combretum duarteanum, Medicinal plants, Combretaceae, Inflammatory bowel disease, Anti-inflammatory intestinal activity
Como citar
World Journal Of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 23, n. 8, p. 1353-1366, 2017.