Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
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Data
2012-03-01
Autores
Chaves de Souza, Joao Antonio [UNESP]
Rossa Júnior, Carlos [UNESP]
Garlet, Gustavo Pompermaier
Boas Nogueira, Andressa Vilas [UNESP]
Cirelli, Joni Augusto [UNESP]
Título da Revista
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Título de Volume
Editor
Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru
Resumo
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies for inhibiting signal transduction pathways involved in inflammation. Pharmacological inhibitors of MAPK, NF kappa B and JAK/STAT pathways are being developed to manage rheumatoid arthritis, periodontal disease and other inflammatory diseases. Through these agents, inflammatory mediators can be inhibited at cell signaling level, interfering on transcription factors activation and inflammatory gene expression. Although these drugs offer great potential to modulate host response, their main limitations are lack of specificity and developments of side effects. After overcoming these limitations, adjunctive host modulating drugs will provide new therapeutic strategies for periodontal treatment.
Descrição
Palavras-chave
Periodontitis, Signal transduction, Janus kinases, STAT transcription factors, Mitogen-activated protein kinases, NF-kappa B
Como citar
Journal of Applied Oral Science. Bauru-sp: Univ São Paulo Fac Odontologia Bauru, v. 20, n. 2, p. 128-138, 2012.