Central muscarinic receptors signal pilocarpine-induced salivation

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Data

2003-12-01

Autores

Takakura, ACT
Moreira, T. S.
Laitano, S. C.
De Luca, L. A.
Renzi, Antonio [UNESP]
Menani, José Vanderlei [UNESP]

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Editor

Sage Publications Inc

Resumo

Although cholinergic agonists such as pilocarpine injected peripherally can act directly on salivary glands to induce salivation, it is possible that their action in the brain may contribute to salivation. To investigate if the action in the brain is important to salivation, we injected pilocarpine intraperitoneally after blockade of central cholinergic receptors with atropine methyl bromide (atropine-mb). In male Holtzman rats with stainless steel cannulas implanted into the lateral ventricle and anesthetized with ketamine, atropine-mb (8 and 16 nmol) intracerebroventricularly reduced the salivation induced by pilocarpine (4 mumol/kg) intraperitoneally (133 +/- 42 and 108 +/- 22 mg/7 min, respectively, vs. saline, 463 +/- 26 mg/7 min), but did not modify peripheral cardiovascular responses to intravenous acetylcholine. Similar doses of atropine-mb intraperitoneally also reduced pilocarpine-induced salivation. Therefore, systemically injected pilocarpine also enters the brain and acts on central muscarinic receptors, activating autonomic efferent fibers to induce salivation.

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Palavras-chave

muscarinic receptors, acetylcholine, atropine, salivary glands, parasympathetic

Como citar

Journal of Dental Research. Thousand Oaks: Sage Publications Inc., v. 82, n. 12, p. 993-997, 2003.