Water deprivation and the double- depletion hypothesis: common neural mechanisms underlie thirst and salt appetite
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Data
2007-05-01
Autores
De Luca, L.A. Jr [UNESP]
Vendramini, R.C. [UNESP]
Pereira, D.T.B. [UNESP]
Colombari, D.A.S. [UNESP]
David, R.B. [UNESP]
Paula, P.M. [UNESP]
Menani, José Vanderlei [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Associação Brasileira de Divulgação Científica (ABRADIC)
Resumo
Water deprivation-induced thirst is explained by the double-depletion hypothesis, which predicts that dehydration of the two major body fluid compartments, the extracellular and intracellular compartments, activates signals that combine centrally to induce water intake. However, sodium appetite is also elicited by water deprivation. In this brief review, we stress the importance of the water-depletion and partial extracellular fluid-repletion protocol which permits the distinction between sodium appetite and thirst. Consistent enhancement or a de novo production of sodium intake induced by deactivation of inhibitory nuclei (e.g., lateral parabrachial nucleus) or hormones (oxytocin, atrial natriuretic peptide), in water-deprived, extracellular-dehydrated or, contrary to tradition, intracellular-dehydrated rats, suggests that sodium appetite and thirst share more mechanisms than previously thought. Water deprivation has physiological and health effects in humans that might be related to the salt craving shown by our species.
Descrição
Palavras-chave
Water deprivation, Dehydration, Mineral preference, Sodium appetite, Cravings
Como citar
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 5, p. 707-712, 2007.