Antibacterial activity of monoacetylated alkyl gallates against Xanthomonas citri subsp citri
Carregando...
Arquivos
Data
2018-08-01
Autores
Savietto, Abigail [UNESP]
Polaquini, Carlos Roberto [UNESP]
Kopacz, Malgorzata
Scheffers, Dirk-Jan
Marques, Beatriz Carvalho [UNESP]
Regasini, Luis Octavio [UNESP]
Ferreira, Henrique [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Springer
Resumo
Asiatic citrus canker (ACC) is an incurable disease of citrus plants caused by the Gram-negative bacterium Xanthomonas citri subsp. citri (X. citri). It affects all the commercially important citrus varieties in the major orange producing areas around the world. Control of the pathogen requires recurrent sprays of copper formulations that accumulate in soil and water reservoirs. Here, we describe the improvement of the alkyl gallates, which are potent anti-X. citri compounds, intended to be used as alternatives to copper in the control of ACC. Acetylation of alkyl gallates increased their lipophilicity, which resulted in potentiation of the antibacterial activity. X. citri exposed to the acetylated compounds exhibited increased cell length that is consistent with the disruption of the cell division apparatus. Finally, we show that inhibition of cell division is an indirect effect that seemed to be caused by membrane permeabilization, which is apparently the primary target of the acetylated alkyl gallates.
Descrição
Palavras-chave
Citrus canker, Gallic acid, Cell division, Membrane disruption
Como citar
Archives Of Microbiology. New York: Springer, v. 200, n. 6, p. 929-937, 2018.