Can genetic factors compromise the success of dental implants? A systematic review and meta-analysis
Carregando...
Arquivos
Data
2018-09-06
Autores
Santiago Junior, Joel Ferreira
Biguetti, Claudia Cristina [UNESP]
Matsumoto, Mariza Akemi [UNESP]
Kudo, Guilherme Abu Halawa
da Silva, Raquel Barroso Parra [UNESP]
Saraiva, Patrícia Pinto
Fakhouri, Walid D.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Dental implants provide a predictable treatment option for partial and complete edentulism via the placement of a fixed permanent artificial root to support prosthetic dental crowns. Despite the high survival rates, long-term dental implant failures are still reported, leading to implant removals and additional financial and health burdens. While extrinsic factors that improve the success rate of implants have been well explored, the impact of genetic factors on this matter is poorly understood. A systematic review and meta-analysis study was conducted to determine whether genetic factors contribute to an increased risk of dental implant failures. A comprehensive search for peer-reviewed articles on dental implants and genetic factors was performed using various literature database libraries. The study design was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, and the obtained records were registered in the International Prospective Register of Systematic Reviews (PROSPERO) database. According to the exclusion/inclusion criteria, 13 studies were eligible for this study out of 809 articles. The meta-analysis of the combined association studies of DNA variations and dental implants did not indicate an increased risk for implant failure due to DNA variations in IL-1B, IL-10 and TNF-α. This study emphasizes the need for larger randomized controlled clinical trials to inform clinicians and patients about the role of genetic factors on dental implant survival and the success rate in healthy and compromised patients.
Descrição
Palavras-chave
Bone quality, Bone regeneration, Dental implants, Genetic factors, Survival rate
Como citar
Genes, v. 9, n. 9, 2018.